The goal for this project was to test Psilocybin and Psilocin for cellular bioavailability in a preclinical bioassay. Psilocybin is present in some hallucinogenic mushrooms and is converted into Psilocin when it is absorbed into the human body.
Psilocin is the active hallucinogenic compound.
Both Psilocin and Psilocybin had antioxidant capacity, with Psilocin being superior to Psilocybin. Psilocin clearly showed a good cellular antioxidant protection of red blood cells, as it robustly reduced the intracellular oxidative stress in the CAP-e bioassay, demonstrating cellular bioavailability.